Cover: C2– vs C1-Symmetry in Assymetric Catalysis

Adv. Synth. Catal. , 2016, 358, 864–868.

 

Quest for Efficient Catalysts based on Zinc tert-Butyl Peroxides for Asymmetric Epoxidation of Enones: C2– vs C1-Symmetric Auxiliaries


Abdul Raheem Keeri,ab Iwona Justyniak,c Janusz Jurczak,ad Janusz Lewińskib

Faculty of Chemistry, University of Warsaw, Pasteura 1, 02093 Warsaw, Poland
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego-3, 00664 Warsaw, Poland
Institute of Physical Chemistry, Polish Academy of Science, Kasprzaka 44/52, 01224 Warsaw, Poland
Institute of Organic Chemistry, Polish Academy of Science, Kasprzaka 44/52, 01224 Warsaw, Poland

DOI: 10.1002/adsc.201500764.
First published online 5 Jan 2016.

Front Cover, Very Important Paper.

Zinc tert-butyl peroxide-based catalysts for the asymmetric epoxidation of enones using tert-butyl hydroperoxide as an oxidant have been developed. A comparative study of chiral monoanioninc N,N′-bidentate ligands, C2-symmetric bisoxazolinates and C1-symmetric enaminooxazolinates, revealed excellent performance of C1-symmetric auxiliary ligands on catalytic asymmetric epoxidation of enones (up to 96% yield, 91% ee).

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Paper on the Wiley Online Library website